منابع مشابه
Animal Models for HIV Cure Research
The HIV-1/AIDS pandemic continues to spread unabated worldwide, and no vaccine exists within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot clear the virus from the infected patient. A cure for HIV-1 is badly needed to stop both the spread of the virus in human populations and disease progression in infected individuals. A safe and effective cure strategy f...
متن کاملAnimal models in HIV cure research
Current HIV antiretroviral therapy (ART) successfully inhibits viral replication in the majority of HIV-infected individuals. However, ART is not curative and lifelong adherence is required. Despite the undisputed benefit of ART, long-lived latently infected cells that carry HIV-integrated DNA remain. Hence, upon ART interruption, HIV-infected subjects experience viral rebound. Interestingly, s...
متن کاملTargeting the latent reservoir to achieve functional HIV cure
While highly active anti-retroviral therapy has greatly improved the lives of HIV-infected individuals, current treatments are unable to completely eradicate the virus. This is due to the presence of HIV latently infected cells which harbor transcriptionally silent HIV. Latent HIV does not replicate or produce viral proteins, thereby preventing efficient targeting by anti-retroviral drugs. Stra...
متن کاملPreeclampsia: animal models for a human cure.
P reeclampsia (PE) affects ∼5% of human pregnancies and is a leading cause of perinatal mortality, preterm birth, and maternal morbidity (1). Through positive effects on vascular tone and glomerular capillary health, vascular endothelial growth factor (VEGF) and placental growth factor (PGF) are necessary for normal pregnancy (2–4). In PE, these proteins are antagonized by excessive placental p...
متن کاملTowards an HIV cure
Given the challenge of delivering complex, expensive and potentially harmful antiretroviral therapy (ART) on a global level, there is intense interest in the development of short-term, well-tolerated regimens that allow individuals to interrupt therapy indefinitely without experiencing a rebound in viremia. This so-called "cure" or "remission" might be due to complete eradication of all replica...
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ژورنال
عنوان ژورنال: Current Opinion in HIV and AIDS
سال: 2016
ISSN: 1746-630X
DOI: 10.1097/coh.0000000000000290